Problem: Even on a fairly modern PC running Core i7, Internet Explorer 8 seems to take significant time to load if anti-malware softwares that relies on Internet Explorer’s Zones to block sites (> 100,000+ records). Since Windows Explorer is tightly integrated with Internet Explorer, it slows down significantly as well.
Solution: There are no permanent solutions at the moment other than deleting all the keys under zone maps set by your anti-malware software: HKLM\SOFTWARE\Microsoft\Windows\CurrentVersion\Internet Settings\ZoneMap\